Juston Osborne studies the pathophysiological mechanisms underlying the risk, development, and progression of psychotic disorders. His long-term research goal is to refine our etiological understanding of the neurobiological processes that underlie psychosis to improve early intervention, reduce illness progression, and optimize recovery.

To achieve this goal, he uses multiple methods (e.g., behavioral, EEG, neuroimaging) with prospective longitudinal research designs to examine distinct, but mechanistically related, risk factors in individuals across the psychosis spectrum, such as substance use (i.e., cannabis) and socio-affective deficits. A major area of his research examines how motor system abnormalities, particularly abnormalities in the cerebellum and its relays, contribute to the onset and progression of psychosis symptoms. His recent research has focused on unpacking the relationship between cannabis use and psychosis risk across adolescence, and the application of cerebellar non-invasive brain stimulation to elucidate the mechanisms of hallucinations and delusions in schizophrenia.

Selected Publications

• Osborne, K.J., Barch, D.M., Jackson, J.J., Karcher, N., R. (2025). Psychosis spectrum symptoms before and after adolescent cannabis use initiation. JAMA Psychiatry, 82(2), 181-190.
• Osborne, K. J., Walther, S., & Mittal, V. A. (2024). Motor actions across psychiatric disorders: A research domain criteria (RDoC) perspective. Clinical Psychology Review, 114, 102511.
• Osborne, K.J., Zhang, W., Gupta, T., Farrens, J., Geiger, M., Kraus, B., Krugel, C., Nusslock, R., Kappenman, E.S., & Mittal, V.A. (2023). Clinical high-risk for psychosis syndrome is associated with reduced neural responding to unpleasant images. Journal of Psychopathology and Clinical Science, 132(8), 1060–1071.
• Osborne, K.J., Zhang, W., Geiger, M., Farrens, J., Kraus, B., Glazer, J., Nusslock, R., Kappenman, E.S., & Mittal, V.A. (2022). Neural mechanisms of motor dysfunction in individuals at clinical high-risk for psychosis: Evidence for impairments in motor activation. Journal of Psychopathology and Clinical Science, 131(4), 375–391.
• Osborne, K.J., Kraus, B., Curran, T., Earls, H., & Mittal, V.A. (2022). An event-related potential investigation of early visual processing deficits in youth at clinical high-risk for psychosis. Schizophrenia Bulletin, 48, 90-99.
• Osborne, K.J., Damme, K.S.F., Gupta, T., Dean, D.J., Bernard, J.A., & Mittal, V.A. (2021). Timing dysfunction and cerebellar network abnormalities in youth at clinical high-risk for psychosis. Psychological Medicine, 51(8), 1289-1298.